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Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa

Ibraham, Sabrin and Ebel, Rainer and Wray, Victor and Muller, Werner E.G. and Edrada-Ebel, RuAngelie and Proksch, Peter (2008) Diacarperoxides, norterpene cyclic peroxides from the sponge Diacarnus megaspinorhabdosa. Journal of Natural Products, 71 (8). pp. 1358-1364. ISSN 0163-3864

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Abstract

Chemical investigation of the hexane extract of the sponge Diacarnus megaspinorhabdosa provided a series of new norterpene derivatives including three norditerpene cyclic peroxides, diacarperoxides A, B, and C (1 to 3), four norsesterterpene cyclic peroxides, diacarperoxides D to G (4 to 7), and the acyclic norsesterterpene diacardiol A (8). In addition, known norterpene peroxide congeners were also isolated, which included a known norsesterterpene cyclic peroxide (9), nuapapuin A methyl ester (10), epimuqubilin B (11), methyl-2-epinuapapuinoate (12), and methyl diacarnoate A (13). The structures of the new compounds were established on the basis of one- and two-dimensional NMR spectroscopic studies (1H, 13C, COSY, HMQC, HMBC, and ROESY) as well as by mass spectrometric analyses. The relative configuration of chiral centers at C-2, C-3, and C-6 was assigned by established empirical rules. All compounds were evaluated for their cytotoxic properties in vitro using several human as well as murine cancer cell lines.

Item type: Article
ID code: 13260
Keywords: diacarperoxides, norterpene cyclic peroxides, sponges, diacarnus megaspinorhabdosa, plants, pharmacology, drugs, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 13 Oct 2009 15:42
    Last modified: 04 Sep 2014 22:53
    URI: http://strathprints.strath.ac.uk/id/eprint/13260

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