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Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense

Aly, Amal H. and Edrada-Ebel, RuAngelie and Indriani, Ine Dewl and Wray, Victor and Muller, Werner E.G. and Totzke, Frank and Zirrglebel, Ute and Schachtele, Christoph and Kubbutat, Michael H.G. and Lin, W.H. and Proksch, Peter and Ebel, Rainer (2008) Cytotoxic metabolites from the fungal endophyte Alternaria sp. and their subsequent detection in its host plant Polygonum senegalense. Journal of Natural Products, 71 (6). pp. 972-980. ISSN 0163-3864

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Abstract

From the Egyptian medicinal plant Polygonum senegalense the fungal endophyte Alternaria sp. was isolated. Extracts of the fungus grown either in liquid culture or on solid rice media exhibited cytotoxic activity when tested in vitro against L5178Y cells. Chromatographic separation of the extracts yielded 15 natural products, out of which seven were new compounds, with both fungal extracts differing considerably with regard to their secondary metabolites. Compounds 1, 2, 3, 6, and 7 showed cytotoxic activity with EC50 values ranging from 1.7 to 7.8 µg/mL. When analyzed in vitro for their inhibitory potential against 24 different protein kinases, compounds 1−3, 5−8, and 15 inhibited several of these enzymes (IC50 values 0.22−9.8 µg/mL). Interestingly, compounds 1, 3, and 6 were also identified as constituents of an extract derived from healthy leaves of the host plant P. senegalense, thereby indicating that the production of natural products by the endophyte proceeds also under in situ conditions within the plant host.

Item type: Article
ID code: 13259
Keywords: cytotoxic metabolites, fungal endophyte, alternaria sp, polygonum senegalense, plants, drug delivery, pharmacology, drugs, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 13 Oct 2009 15:39
    Last modified: 04 Sep 2014 22:44
    URI: http://strathprints.strath.ac.uk/id/eprint/13259

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