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Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata

Xu, Jing and Kjer, Julia and Sendker, Jandirk and Wray, Victor and Guan, Huashi and Edrada-Ebel, RuAngelie and Lin, Wenhan and Wu, Jun and Proksch, Peter (2009) Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. Journal of Natural Products, 72 (4). pp. 662-665. ISSN 0163-3864

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Abstract

Six new chromones, named pestalotiopsones A−F (1−6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A−F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.

Item type: Article
ID code: 13256
Keywords: chromones, endophytic fungus, pestalotiopsis sp, chinese mangrove plant, rhizophora mucronata, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Organic Chemistry, Drug Discovery, Pharmaceutical Science, Molecular Medicine, Complementary and alternative medicine, Analytical Chemistry, Pharmacology
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 13 Oct 2009 15:23
    Last modified: 02 Jun 2014 16:58
    URI: http://strathprints.strath.ac.uk/id/eprint/13256

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