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Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

Liu, Hongbing and Edrada-Ebel, RuAngelie and Ebel, Rainer and Wang, Yao and Schulz, Barbara and Draeger, Siegfried and Muller, Werner E.G. and Wray, Victor and Lin, Wenhan and Proksch, Peter (2009) Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. Journal of Natural Products, 72 (9). pp. 1585-1588. ISSN 0163-3864

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Abstract

Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).