Picture of wind turbine against blue sky

Open Access research with a real impact...

The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

The Energy Systems Research Unit (ESRU) within Strathclyde's Department of Mechanical and Aerospace Engineering is producing Open Access research that can help society deploy and optimise renewable energy systems, such as wind turbine technology.

Explore wind turbine research in Strathprints

Explore all of Strathclyde's Open Access research content

Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula

Liu, Hongbing and Edrada-Ebel, RuAngelie and Ebel, Rainer and Wang, Yao and Schulz, Barbara and Draeger, Siegfried and Muller, Werner E.G. and Wray, Victor and Lin, Wenhan and Proksch, Peter (2009) Drimane sesquiterpenoids from the fungus Aspergillus ustus isolated from the marine sponge Suberites domuncula. Journal of Natural Products, 72 (9). pp. 1585-1588. ISSN 0163-3864

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Seven new drimane sesquiterpenoids (1−3, 6−9), along with the known compounds deoxyuvidin B (4), strobilactone B (5), and RES-1149-2 (10), were obtained from cultures of the fungus Aspergillus ustus, which was isolated from the marine sponge Suberites domuncula. Their structures were established by means of spectroscopic analyses including one- and two-dimensional NMR spectroscopy and high-resolution MS. Compounds 6, 7, and 10 showed cytotoxic activity against a panel of tumor cell lines, including L5178Y, HeLa, and PC12 cells, with 7 being the most active (EC50 against L5178Y cell line: 0.6 μg/mL).