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Oxidative stress and the endothelium

Wadsworth, Roger M. (2008) Oxidative stress and the endothelium. Experimental Physiology, 93. pp. 155-157. ISSN 0958-0670

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Abstract

Oxidative stress plays a major role in cardiovascular disease. Despite the widespread acceptance of this view, it remains a challenge to establish the importance of this link in specific disease states because of the numerous pro-oxidant substances and also the many endogenous antioxidant systems that contribute to the imbalance that we term 'oxidative stress'. It seems that the vascular endothelium is particularly sensitive to oxidative stress, and this is one of the mechanisms that results in widespread endothelial dysfunction in most cardiovascular diseases. Moreover, when the endothelium becomes diseased it is itself a source of oxidative stress; however, other components of the vasculature, such as the adventitia, are also important sources of oxidative stress. The symposium Oxidative stress and the endothelium at Life Sciences Meeting, Glasgow, Thursday 12th July 2007 aimed to bring together important new data and concepts that are contributing to the rapid advances in our understanding of this area. Mark Kearney spoke on Insulin resistance and endothelial cell dysfunction, Patrick Pagano spoke on The adventitial fibroblast NAD(P)H oxidase as a paracrine mediator of vascular hypertrophy: signal for vascular disease?, James Lieper spoke on Disruption of methylarginine metabolism impairs vascular homeostasis, and David Newby spoke on Endothelial dysfunction and atherothrombosis.