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Penetration of topical and subconjunctival corticosteroids into human aqueous humour and its therapeutic significance

Awan, M.A. and Agarwal, P.K. and Watson, D.G. and McGhee, Charles N.J. and Dutton, G.N. (2009) Penetration of topical and subconjunctival corticosteroids into human aqueous humour and its therapeutic significance. British Journal of Ophthalmology, 93 (6). pp. 708-713. ISSN 0007-1161

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Abstract

Topical and subconjunctival corticosteroids are some of the most effective and compelling treatment options in ocular inflammatory diseases. A systematic review of literature indexed by Ovid MEDLINE & EMBASE was performed up to December 2008. There are few studies on their aqueous penetration in human subjects. This review article discusses the penetration of different ocular corticosteroids into human aqueous humour along with the therapeutic implications on management of ocular surface diseases, immune-related corneal diseases, anterior uveitis and postoperative anti-inflammatory use. In the context of the paucity of well-constructed, prospective clinical trials comparing the efficacy of different corticosteroids, it provides guiding principles for the use of topical corticosteroids. Dexamethasone alcohol 0.1% and prednisolone acetate 1% are potent corticosteroids, but the latter achieves the highest aqueous concentration within 2 h and maintains higher levels for 24 h. Subconjunctival corticosteroids provide very high concentrations in the aqueous which maintain higher concentrations for longer periods.

Item type: Article
ID code: 13202
Keywords: topical corticosteroids, subconjunctival corticosteroids, human aqueous humour, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Ophthalmology, Cellular and Molecular Neuroscience, Sensory Systems
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Professional Services > Information Services
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 12 Oct 2009 16:37
    Last modified: 04 Sep 2014 23:38
    URI: http://strathprints.strath.ac.uk/id/eprint/13202

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