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IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response

Sureshbabu, Angara and Okajima, Hiroshi and Yamanaka, Daisuke and Shastri, Surya and Tonner, Elizabeth and Rae, Colin and Szymanowska, M. and Shand, J.H. and Takahashi, Shin-Ichiro and Beattie, J. and Allan, G.J. and Flint, D.J. (2009) IGFBP-5 induces epithelial and fibroblast responses consistent with the fibrotic response. Biochemical Society Transactions, 37. pp. 882-885. ISSN 0300-5127

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Abstract

Fibrosis involves activation of fibroblasts, increased production of collagen and fibronectin and transdifferentiation into contractile myofibroblasts. The process resembles aspects of wound-healing but remains unresolved and can be life-threatening when manifest in the kidneys, lungs and liver, in particular. The causes are largely unknown, but recent suggestions that repetitive micro-injury results in the eventual failure of epithelial cell repair due to replicative senescence are gaining favour. This is consistent with the onset of fibrotic diseases in middle age. Because epithelial injury often involves blood loss, inflammatory responses associated with the fibrotic response have been considered as therapeutic targets. However, this has proved largely unsuccessful and focus is now switching to earlier events in the process. These include EMT (epithelial-mesenchymal transition) and fibroblast activation in the absence of inflammation. TGFβ1 (transforming growth factor-β1) induces both EMT and fibroblast activation and is considered to be a major pro-fibrotic factor. Recently, IGFBP-5 [IGF (insulin-like growth factor)-binding protein-5] has also been shown to induce similar effects on TGFβ1, and is strongly implicated in the process of senescence. It also stimulates migration of peripheral blood mononuclear cells, implicating it in the inflammatory response. In this paper, we examine the evidence for a role of IGFBP-5 in fibrosis and highlight its structural relationship with other matrix proteins and growth factors also implicated in tissue remodelling.

Item type: Article
ID code: 13171
Keywords: epithelial–mesenchymal transition, fibrosis, insulin-like growth factor, senescence, tissue injury, transforming growth factor-β (TGFβ), Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Biochemistry
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 07 Oct 2009 12:17
    Last modified: 28 Mar 2014 05:12
    URI: http://strathprints.strath.ac.uk/id/eprint/13171

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