Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Neither interleukin-4 receptor α expression on CD4+ T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis

Michels, Chesney E. and Scales, Hannah E. and Saunders, Karin A. and McGowan, S. and Brombracher, Frank and Alexander, James and Lawrence, Catherine E. (2009) Neither interleukin-4 receptor α expression on CD4+ T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis. Immunology, 128 (1pt2). e385-e394. ISSN 0019-2805

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

The T helper type 2 (Th2) mediated expulsion of the gastrointestinal nematode Trichinella spiralis requires interleukin-4 receptor α (IL-4Rα) expression on both bone-marrow-derived and non-bone-marrow-derived cells. To more definitively investigate the role of IL-4/IL-13 responsiveness in the development of protective immunity to T. spiralis, cell-specific IL-4Rα signalling on CD4+ T cells (Lckcre IL-4Rα−/flox) and macrophages/neutrophils (LysMcre IL-4Rα−/flox) was analysed on the BALB/c background. Infection of wild-type and control IL-4Rα−/flox mice induced a Th2-type immune response with elevated IL-4 cytokine production, parasite-specific immunoglobulin G1 (IgG1), total IgE, intestinal mastocytosis and enteropathy. In contrast, global IL-4Rα-deficient BALB/c mice showed reduced worm expulsion, antibody production, intestinal mastocytosis and gut pathology. BALB/c mice generated with cell-specific deletion of IL-4Rα on CD4+ T lymphocytes or macrophages/neutrophils, controlled gastrointestinal helminth infection by eliciting a protective immune response comparable to that observed with wild-type and IL-4Rα−/flox controls. Together, this shows that the development of host protective Th2 responses accompanied by parasite loss is independent of IL-4Rα expression on CD4+ T cells and macrophages/neutrophils.

Item type: Article
ID code: 13168
Keywords: cell-specific interleukin-4 receptor α transgenic mice, gastrointestinal nematodes, mastocytosis, T helper immune response, trichinella spiralis, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Immunology, Immunology and Allergy
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 07 Oct 2009 11:32
    Last modified: 04 Sep 2014 23:05
    URI: http://strathprints.strath.ac.uk/id/eprint/13168

    Actions (login required)

    View Item