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In situ detection of pterins by SERS

Stevenson, Ross and Stokes, Robert J. and MacMillan, Donna and Armstrong, David and Faulds, Karen and Wadsworth, Roger and Kununthur, Suma and Suckling, Colin J. and Graham, Duncan (2009) In situ detection of pterins by SERS. Analyst, 134. pp. 1561-1564. ISSN 0003-2654

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Abstract

Surface enhanced Raman scattering (SERS) has been used to detect specific pterin molecules at sub-nanomolar concentrations. SERS is fast becoming a widely used technique for the sensitive and specific detection of multiple analytes. The information-rich and concentration-dependent spectra obtained from SERS make the technique ideally placed for high speed, low cost analysis of almost any analyte. Further, to show the feasibility of SERS in the detection of biologically relevant targets, a synthetic pterin analogue of the naturally occurring pterin cofactor, tetrahydrobiopterin, has been detected at a series of concentrations and the method used for the successful detection of the synthetic pterin in mouse serum. In this analysis, spectroscopic collection was optimized for water-based pteridine derivatives using two visible wavelengths of excitation (514.5 and 632.8 nm) and differing mesoscopic metal nanoparticles allowing the limits of detection to be calculated.

Item type: Article
ID code: 13163
Keywords: in situ detection, SERS, pharmacology, biomedical sciences, pterins, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Biochemistry, Spectroscopy, Environmental Chemistry, Analytical Chemistry, Electrochemistry
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 07 Oct 2009 10:35
    Last modified: 28 Mar 2014 05:12
    URI: http://strathprints.strath.ac.uk/id/eprint/13163

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