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Rapid cell mapping using nanoparticles and SERRS

Stokes, Robert J. and McKenzie, Fiona and McFarlane, Emma and Ricketts, Alastair and Tetley, L. and Faulds, Karen and Alexander, J. and Graham, Duncan (2009) Rapid cell mapping using nanoparticles and SERRS. Analyst, 134 (1). pp. 170-175. ISSN 0003-2654

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Abstract

Bone marrow-derived immune cells (macrophages) treated with gold and silver nanoparticles before fixation and dye staining have been analysed by multiple wavelength line scanning surface enhanced resonance Raman scattering (SERRS) mapping. The method yields high selectivity and sensitivity within short analysis times, identifying nanoparticle aggregates in secondary lysosomes. Using routine cell stains, the output from fluorescence, Raman and SERRS is quantified at four wavelengths of excitation, demonstrating the potential at longer biologically compatible wavelengths of using nanoparticles with cell stains for superior cell mapping.

Item type: Article
ID code: 13162
Keywords: rapid cell mapping, nanoparticles, SERRS, pharmacology, biomedical sciences, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Biochemistry, Spectroscopy, Environmental Chemistry, Analytical Chemistry, Electrochemistry
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Pure and Applied Chemistry
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 06 Oct 2009 15:23
    Last modified: 28 Mar 2014 05:11
    URI: http://strathprints.strath.ac.uk/id/eprint/13162

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