Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

A methodology for investigating protein adhesion and adsorption to microarrayed combinatorial libraries

Taylor, Michael and Urquhart, Andrew J. and Anderson, Daniel G. and Williams, Philip M. and Langer, Robert S. and Alexander, Morgan R. and Davies, Martyn C. (2008) A methodology for investigating protein adhesion and adsorption to microarrayed combinatorial libraries. Macromolecular Rapid Communications, 29 (15). pp. 1298-1302. ISSN 1022-1336

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Here, we report the use of fluorescently labelled proteins to study protein adsorption to microarrayed synthetic polymers for the first time, indicating that this method is appropriate for the study of protein adsorption on these arrays. To investigate protein adhesion directly we use atomic force microscopy (AFM) to measure the force of adhesion between a protein-coated probe and the arrayed polymers. Both approaches show promise as methods for screening protein interactions with polymers in a microarray format. Comparison of these very different measures of protein-surface interactions indicate a good correlation.