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Pharmacodynamic evaluation of oral estradiol nanoparticles in estrogen deficient (ovariectomized) high-fat diet induced hyperlipidemic female rat model

Mittal, G. and Chandraiah, G. and Ramarao, P. and Kumar, M.N.V. Ravi (2008) Pharmacodynamic evaluation of oral estradiol nanoparticles in estrogen deficient (ovariectomized) high-fat diet induced hyperlipidemic female rat model. Pharmaceutical Research, 26 (1). pp. 218-223. ISSN 0724-8741

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Abstract

It is believed that estrogen deficiency contributes importantly to the pathogenesis of menopausal metabolic syndrome and symptoms can be ameliorated with estradiol therapy. The present study reports efficacy of 17-β estradiol encapsulated nanoparticles in treating the postmenopausal dyslipidemic condition. Estradiol encapsulated poly(lactide-co-glycolide) (PLGA) nanoparticles were prepared by emulsion-diffusion-evaporation method and evaluated in estrogen deficient (ovariectomized) high fat diet induced hyperlipidemic rat model. The results obtained showed that estradiol nanoparticles were equally/more effective in treatment of estrogen deficient hyperlipidemic conditions at three times reduced dose and frequency in comparison to that of drug suspension administered orally. Together, these results demonstrate the ability of nanoparticles in improving oral bioavailability/efficacy of estradiol.

Item type: Article
ID code: 13154
Keywords: bioavailability, estrogen therapy, lipid profile, nanoparticles, oral drug delivery, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Organic Chemistry, Pharmaceutical Science, Molecular Medicine, Biotechnology, Pharmacology, Pharmacology (medical)
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 05 Oct 2009 16:12
    Last modified: 04 Sep 2014 22:23
    URI: http://strathprints.strath.ac.uk/id/eprint/13154

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