Fabbiani, Francesca P.A. and Dittrich, Birger and Florence, A.J. and Gelbrich, T. and Hursthouse, M.B. and Kuhs, Werner F. and Shankland, N. and Sowa, Heidrum (2008) Crystal structures with a challenge: high-pressure crystallisation of ciprofloxacin sodium salts and their recovery to ambient pressure. CrystEngComm, 11. pp. 1396-1406. ISSN 1466-8033
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
Two novel sodium salts of the antibiotic ciprofloxacin were crystallised at pressures of 0.25 and 0.6 GPa and subsequently recovered to ambient pressure. The structures are the first reported examples of ciprofloxacin chelating a Group IA monovalent cation. Ambient-pressure crystallisation of the same solution used for high-pressure experiments, yielded crystals of the known hexahydrate. In a parallel study, the previously unknown structure of anhydrous ciprofloxacin was determined from powder diffraction data. The structures are described and compared using the XPac method.
| Item type: | Article |
|---|---|
| ID code: | 13148 |
| Keywords: | crystal structures, high-pressure crystallisation, ciprofloxacin sodium salts, ambient pressure, biomedical sciences, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology |
| Subjects: | Medicine > Therapeutics. Pharmacology Medicine > Pharmacy and materia medica Science > Microbiology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Pharmaceutical Sciences |
| Related URLs: | |
| Depositing user: | Ms Ann Barker-Myles |
| Date Deposited: | 05 Oct 2009 15:33 |
| Last modified: | 12 Mar 2012 10:56 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/13148 |
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