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PAR-2 mediates increased inflammatory cell adhesion and neointima formation following vascular injury in the mouse

Tennant, G.M. and Wadsworth, Roger M. and Kennedy, Simon (2007) PAR-2 mediates increased inflammatory cell adhesion and neointima formation following vascular injury in the mouse. Atherosclerosis, 198 (1). pp. 57-64. ISSN 0021-9150

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Abstract

Activation of PAR-2 in the vasculature affects vascular tone and adhesion of leukocytes to the endothelium. Since adhesion of leukocytes is increased following vascular injury and is important in determining the extent of neointima formation, we hypothesised that mice lacking PAR-2 may have reduced neointima formation following vascular injury. PAR-2 activating peptides and trypsin induced endothelium-dependent relaxation of mouse carotid artery which was absent in the knockout mouse. Lack of a PAR-2 receptor did not affect lymphocyte adhesion under basal conditions, but reduced the contractile response produced by lymphocytes. Twenty-eight days after denuding injury, vessel contraction to lymphocytes was reduced in both strains while lymphocyte adhesion was significantly greater in PAR-2+/+ mice compared to the PAR-2 knockout mice. Neointimal area was markedly reduced in the PAR-2 knockout mouse. Our data show that PAR-2 modulates inflammatory cell adhesion when stimulated and in mice lacking the PAR-2 receptor, adhesion to injured vessels is reduced with a consequent reduction in neointima formation.

Item type: Article
ID code: 12999
Keywords: protease activated receptor-2 (PAR-2), lymphocyte, vascular injury, adhesion, neointima, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Unknown Department
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 01 Sep 2009 16:14
    Last modified: 16 Jul 2013 22:41
    URI: http://strathprints.strath.ac.uk/id/eprint/12999

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