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Protection against aflatoxin B1 in rat - a new look at the link between toxicity, carcinogenicity, and metabolism

Ellis, E. (2009) Protection against aflatoxin B1 in rat - a new look at the link between toxicity, carcinogenicity, and metabolism. Toxicological Sciences, 109 (1). pp. 1-3. ISSN 1096-6080

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Abstract

The ability of aflatoxin B1 (AFB1) to cause liver cancer has a profound impact on the health of many people living in certain regions of the developing world. A clearer understanding of the metabolism of this toxin in model systems may ultimately lead to effective strategies for preventing its harmful effects. To this end, the work described by Roebuck et al. in this issue of Toxicological Sciences illustrates how transgenic animals have been used to determine not only which routes of metabolism prevail in vivo, but also whether these contribute to the prevention of toxicity and carcinogenicity. By overexpressing AKR7A1, an aldo-keto reductase known to be capable of metabolizing AFB1, they also show that in the rat, the link between metabolism, toxicity and carcinogenicity is not as clear-cut as previously thought. Although the AKR7A1 enzyme is shown to be involved in the metabolism of AFB1 in vivo.

Item type: Article
ID code: 12991
Keywords: aflatoxin B1, toxicity, carcinogenicity, metabolism, pharmacology, biomedical sciences, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Toxicology
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Ms Ann Barker-Myles
    Date Deposited: 31 Aug 2009 14:26
    Last modified: 04 Sep 2014 23:12
    URI: http://strathprints.strath.ac.uk/id/eprint/12991

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