Henriquez, Fiona L. and Ingram, Paul R. and Muench, Stephen P. and Rice, David W. and Roberts, Craig W. (2008) Molecular basis for resistance of Acanthamoeba tubulins to all major classes of antitubulin compounds. Antimicrobial Agents and Chemotherapy, 52 (3). pp. 1133-1135. ISSN 0066-4804
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1128/AAC.00355-07
Abstract
Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.
| Item type: | Article |
|---|---|
| ID code: | 12986 |
| Keywords: | molecular chemistry, acanthamoeba tubulins, anti-tubulin compounds, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology |
| Subjects: | Medicine > Therapeutics. Pharmacology Medicine > Pharmacy and materia medica Science > Microbiology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences Faculty of Science > Immunology |
| Related URLs: | |
| Depositing user: | Ms Ann Barker-Myles |
| Date Deposited: | 31 Aug 2009 14:42 |
| Last modified: | 04 Oct 2012 12:42 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/12986 |
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