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Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds

Henriquez, Fiona L. and Ingram, Paul R. and Muench, Stephen P. and Rice, David W. and Roberts, Craig W. (2008) Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds. Antimicrobial Agents and Chemotherapy, 52 (3). pp. 1133-1135. ISSN 0066-4804

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    Abstract

    Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.

    Item type: Article
    ID code: 12986
    Keywords: molecular chemistry, acanthamoeba tubulins, anti-tubulin compounds, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Infectious Diseases, Pharmacology, Pharmacology (medical)
    Subjects: Medicine > Therapeutics. Pharmacology
    Medicine > Pharmacy and materia medica
    Science > Microbiology
    Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
    Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology
    Related URLs:
      Depositing user: Ms Ann Barker-Myles
      Date Deposited: 31 Aug 2009 14:42
      Last modified: 04 Apr 2014 21:20
      URI: http://strathprints.strath.ac.uk/id/eprint/12986

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