Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds

Henriquez, Fiona L. and Ingram, Paul R. and Muench, Stephen P. and Rice, David W. and Roberts, Craig W. (2008) Molecular basis for resistance of acanthamoeba tubulins to all major classes of antitubulin compounds. Antimicrobial Agents and Chemotherapy, 52 (3). pp. 1133-1135. ISSN 0066-4804

[img]
Preview
PDF (Antimicrob. Agents Chemother.-2008-Henriquez-1133-5)
Antimicrob._Agents_Chemother._2008_Henriquez_1133_5.pdf - Published Version

Download (274kB) | Preview

Abstract

Tubulin is essential to eukaryotic cells and is targeted by several antineoplastics, herbicides, and antimicrobials. We demonstrate that Acanthamoeba spp. are resistant to five antimicrotubule compounds, unlike any other eukaryote studied so far. Resistance correlates with critical amino acid differences within the inhibitor binding sites of the tubulin heterodimers.

Item type: Article
ID code: 12986
Keywords: molecular chemistry, acanthamoeba tubulins, anti-tubulin compounds, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Infectious Diseases, Pharmacology, Pharmacology (medical)
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology
Depositing user: Ms Ann Barker-Myles
Date Deposited: 31 Aug 2009 13:42
Last modified: 21 May 2015 10:53
URI: http://strathprints.strath.ac.uk/id/eprint/12986

Actions (login required)

View Item View Item