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Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection

Ierna, Michelle X. and Scales, Hannah E. and Saunders, K.L. and Lawrence, Catherine E. (2008) Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection. Mucosal Immunology, 1. pp. 147-155. ISSN 1933-0219

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Abstract

Expulsion of the gastrointestinal nematode Trichinella spiralis is associated with Th2 responses and intestinal inflammation, which correlate with a marked mast cell (MC) response. To address the role of MC-derived cytokines in the induction of protective responses, WBB6F1-KitW/KitW-v (W/Wv) mice were reconstituted with wild-type, tumor necrosis factor (TNF)--/-, or interleukin (IL)-4-/- bone marrow (BM) prior to infection with T. spiralis. W/Wv mice reconstituted with TNF--/- or IL-4-/- BM expelled the parasite less efficiently and showed diminished enteropathy, whereas protective responses were normal in W/Wv mice reconstituted with wild-type BM and were accompanied by intestinal pathology. MC responses were reduced in W/Wv mice reconstituted with IL-4-/- BM and to a lesser extent when reconstituted with TNF--/-. These results suggest that MC-derived IL-4 and TNF may regulate the induction of protective Th2 responses and intestinal inflammation associated with the expulsion of T. spiralis. Significantly, these studies suggest a role for MC-derived cytokines as autocrine growth factors.

Item type: Article
ID code: 12983
Keywords: mast cells, gastrointestinal helminth infection, pharmacology, biomedical sciences, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology, Immunology, Immunology and Allergy
Subjects: Medicine > Therapeutics. Pharmacology
Medicine > Pharmacy and materia medica
Science > Microbiology
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology
Related URLs:
    Depositing user: Mr Scott Kilgariff
    Date Deposited: 28 Aug 2009 16:04
    Last modified: 04 Sep 2014 22:32
    URI: http://strathprints.strath.ac.uk/id/eprint/12983

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