Alexander, J. and McFarlane, Emma (2008) Can type-1 responses against intracellular pathogens be T helper 2 cytokine dependent? Microbes and Infection, 10 (9). pp. 953-959. ISSN 1286-4579
Full text not available in this repository. (Request a copy from the Strathclyde author)Abstract
While control of intracellular pathogens, such as the protozoan Leishmania, is dependent on the generation of type-1 immune responses, the role of T helper 2 cytokines in the disease process is more controversial. Traditionally these cytokines were perceived as counter-regulating type-1 responses and promoting disease exacerbation. Nevertheless a substantial body of evidence now exists suggesting that the development of effective type-1 immunity can involve the significant involvement of the Th2 cytokines IL-4 and IL-13. This article reviews, using Leishmania species in particular, the circumstances under which these cytokines can promote protective type-1 immunity.
| Item type: | Article |
|---|---|
| ID code: | 12981 |
| Keywords: | th1, th2, il-4, il-13, leishmania, intracellular pathogens, pharmacology, Therapeutics. Pharmacology, Pharmacy and materia medica, Microbiology |
| Subjects: | Medicine > Therapeutics. Pharmacology Medicine > Pharmacy and materia medica Science > Microbiology |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Mr Scott Kilgariff |
| Date Deposited: | 28 Aug 2009 16:00 |
| Last modified: | 04 Oct 2012 12:45 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/12981 |
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