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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Fairhead, Michael and Johnson, Kenneth A. and Kowatz, James H. and McMahon, Stephen A. and Carter, Lester G. and Oke, Muse and Liu, Huanting and Naismith, James H. and van der Walle, Christopher F. (2008) Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras. Chemical Communications (London), 2008 (15). pp. 1765-1767. ISSN 0009-241X

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Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5A ˚ crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.