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A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function

Whalley, H C and Pickard, B S and McIntosh, A M and Zuliani, R and Johnstone, E C and Blackwood, D H R and Lawrie, S M and Muir, W J and Hall, J (2009) A GRIK4 variant conferring protection against bipolar disorder modulates hippocampal function. Molecular Psychiatry, 14 (5). pp. 467-468. ISSN 1359-4184

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Abstract

The GRIK4 gene encodes the kainate glutamate receptor subunit, KA1, which is expressed at high levels in the hippocampus.1, 2 Cytogenetic and associated studies have shown that genetic variation in GRIK4 alters risk for bipolar disorder and schizophrenia.3 Recently a common insertion–deletion (indel) variant was identified in the 3′ untranslated region (3′UTR) of the GRIK4 gene, which alters GRIK4 expression in the hippocampus and confers protection against bipolar disorder.4 Here we show that the same GRIK4 variant modulates hippocampal activity as assessed by functional magnetic resonance imaging.