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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Robust experimental design and feature selection in signal transduction pathway modeling

He, F. and Brown, M. and Yue, H. and Yeung, L.F. (2008) Robust experimental design and feature selection in signal transduction pathway modeling. In: IEEE International Joint Conference on Neural Networks, 2008. IJCNN 2008. IEEE, Hong Kong, China, pp. 1544-1551. ISBN 978-1-4244-1820-6

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Abstract

Due to the general lack of experimental data for biochemical pathway model identification, cell-level time series experimental design is particularly important in current systems biology research. This paper investigates the problem of experimental design for signal transduction pathway modeling, and in particular, focuses on methods for parametric feature selection. An important problem is the estimation of parametric uncertainty which is a function of the true (but unknown) parameters. In this paper, two ldquorobustrdquo feature selection strategies are investigated The first is a mini-max robust experimental design approach, the second is a sampled experimental design method inspired by the Morris global sensitivity analysis. The two approaches are analyzed and interpreted in terms of a generalized optimal experimental design criterion, and their performance has been compared via simulation on the IkappaB-NF-kappaB pathway feature selection problem.