Yue, H. and Brown, Martin and He, Fei and Jia, J.F. and Kell, Douglas B. (2008) Sensitivity analysis and robust experimental design of a signal transduction pathway system. International Journal of Chemical Kinetics, 40 (11). pp. 730-741. ISSN 0538-8066Full text not available in this repository. (Request a copy from the Strathclyde author)
Experimental design for cellular networks based on sensitivity analysis is studied in this work. Both optimal and robust experimental design strategies are developed for the IκB-NF-κB signal transduction model. Based on local sensitivity analysis, the initial IKK intensity is calculated using an optimal experimental design process, and several scalarization measures of the Fisher information matrix are compared. Global sensitivity analysis and robust experimental design techniques are then developed to consider parametric uncertainties in the model. The modified Morris method is employed in global sensitivity analysis, and a semidefinite programming method is exploited to implement the robust experimental design for the problem of measurement set selection. The parametric impacts on the oscillatory behavior of NF-κB in the nucleus are also discussed.
|Keywords:||identifiability analysis, parameter estimation, gene expression, biology, models, optimization, oscillations, computation, simulation, networks, Electrical engineering. Electronics Nuclear engineering, Biochemistry, Organic Chemistry, Physical and Theoretical Chemistry, Inorganic Chemistry|
|Subjects:||Technology > Electrical engineering. Electronics Nuclear engineering|
|Department:||Faculty of Engineering > Electronic and Electrical Engineering|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||04 Oct 2010 09:11|
|Last modified:||11 Nov 2016 03:46|