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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

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Sensitivity analysis and robust experimental design of a signal transduction pathway system

Yue, H. and Brown, Martin and He, Fei and Jia, J.F. and Kell, Douglas B. (2008) Sensitivity analysis and robust experimental design of a signal transduction pathway system. International Journal of Chemical Kinetics, 40 (11). pp. 730-741. ISSN 0538-8066

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Abstract

Experimental design for cellular networks based on sensitivity analysis is studied in this work. Both optimal and robust experimental design strategies are developed for the IκB-NF-κB signal transduction model. Based on local sensitivity analysis, the initial IKK intensity is calculated using an optimal experimental design process, and several scalarization measures of the Fisher information matrix are compared. Global sensitivity analysis and robust experimental design techniques are then developed to consider parametric uncertainties in the model. The modified Morris method is employed in global sensitivity analysis, and a semidefinite programming method is exploited to implement the robust experimental design for the problem of measurement set selection. The parametric impacts on the oscillatory behavior of NF-κB in the nucleus are also discussed.