Picture of a black hole

Strathclyde Open Access research that creates ripples...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of research papers by University of Strathclyde researchers, including by Strathclyde physicists involved in observing gravitational waves and black hole mergers as part of the Laser Interferometer Gravitational-Wave Observatory (LIGO) - but also other internationally significant research from the Department of Physics. Discover why Strathclyde's physics research is making ripples...

Strathprints also exposes world leading research from the Faculties of Science, Engineering, Humanities & Social Sciences, and from the Strathclyde Business School.

Discover more...

Sensitivity analysis and robust experimental design of a signal transduction pathway system

Yue, H. and Brown, Martin and He, Fei and Jia, J.F. and Kell, Douglas B. (2008) Sensitivity analysis and robust experimental design of a signal transduction pathway system. International Journal of Chemical Kinetics, 40 (11). pp. 730-741. ISSN 0538-8066

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

Experimental design for cellular networks based on sensitivity analysis is studied in this work. Both optimal and robust experimental design strategies are developed for the IκB-NF-κB signal transduction model. Based on local sensitivity analysis, the initial IKK intensity is calculated using an optimal experimental design process, and several scalarization measures of the Fisher information matrix are compared. Global sensitivity analysis and robust experimental design techniques are then developed to consider parametric uncertainties in the model. The modified Morris method is employed in global sensitivity analysis, and a semidefinite programming method is exploited to implement the robust experimental design for the problem of measurement set selection. The parametric impacts on the oscillatory behavior of NF-κB in the nucleus are also discussed.