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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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A radical based addition-elimination route for the preparation of indoles

Murphy, J.A. and Scott, K.A. and Sinclair, R.S. and Martin, C.G. and Kennedy, A.R. and Lewis, N. (2000) A radical based addition-elimination route for the preparation of indoles. Journal of the Chemical Society, Perkin Transactions 1, 2000 (15). pp. 2395-2408. ISSN 1472-7781

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Abstract

Indoles, including tricyclic derivatives, are produced by cyclisations of aryl radicals onto vinyl halides followed by elimination of halide radical and tautomerism of the resulting product; the aryl radicals are produced using clean methodology either by reaction of iodide ions with arenediazonium salts or by reaction of phosphorus-centred radicals with aryl iodides.