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Pulsed UV-light in activation of poliovirus and adenovirus

Lamont, Y. and Rzeutka, A. and Anderson, J.G. and MacGregor, S.J. and Given, M.J. and Deppe, C. and Cook, N. (2007) Pulsed UV-light in activation of poliovirus and adenovirus. Letters in Applied Microbiology, 45 (5). pp. 564-567. ISSN 0266-8254

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Abstract

To study the pulsed ultraviolet (UV) inactivation of poliovirus and adenovirus. Viral suspensions of 2 ml volume were exposed to varying numbers of polychromatic light pulses emitted from a xenon flashlamp. Ten pulses produced an approximately 4 log10 reduction in poliovirus titre, and no infectious poliovirus remained after 25 pulses. With adenovirus, 10 pulses resulted in an approximately 1 log10 reduction in infectivity. Adenovirus required 100 pulses to produce an approximately 3 log10 reduction in infectivity, and 200 pulses to produce a greater than 4 log10 reduction. Adenovirus was more resistant to pulsed UV treatment than poliovirus although both viruses showed susceptibility to the treatment. Pulsed UV-light treatment proved successful in the inactivation of poliovirus and adenovirus, and represents an alternative to continuous-wave UV treatment.