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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Synthesis of a benzotriazole azo dye phosphoramidite for labelling of oligonucleotides

Brown, R. and Smith, W.E. and Graham, D. (2003) Synthesis of a benzotriazole azo dye phosphoramidite for labelling of oligonucleotides. Tetrahedron Letters, 44 (7). pp. 1339-1342. ISSN 0040-4039

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Abstract

The synthesis of a benzotriazole azo dye phosphoramidite and the subsequent use in solid phase synthesis of oligonucleotides is reported. The azo dye is shown as a surface enhanced resonance Raman label for oligonucleotides that is capable of immobilisation of the oligonucleotide on metal surfaces such as silver nanoparticles. (C) 2003 Elsevier Science Ltd. All rights reserved.