Legisa, Matic and Mattey, Michael (2007) Changes in primary metabolism leading to citric acid overflow in aspergillus niger. Biotechnology Letters, 29 (2). pp. 181-190. ISSN 0141-5492Full text not available in this repository. (Request a copy from the Strathclyde author)
For citric acid-accumulating Aspergillus niger cells, the enhancement of anaplerotic reactions replenishing tricarboxylic acid cycle intermediates predisposes the cells to form the product. However, there is no increased citrate level in germinating spores and a complex sequence of developmental events is needed to change the metabolism in a way that leads to an increased level of tricarboxylic acid cycle intermediates in mycelia. A review of physiological events that cause such intracellular conditions, with the special emphasis on the discussion of hexose transport into the cells and regulation of primary metabolism, predominantly of glycolytic flux during the process, is presented.
|Keywords:||anaplerosis, aspergillus niger, citric acid, hexose transport, primary metabolism, Pharmacy and materia medica, Biotechnology|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||16 Nov 2011 11:37|
|Last modified:||22 Mar 2017 10:07|