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Changes in primary metabolism leading to citric acid overflow in aspergillus niger

Legisa, Matic and Mattey, Michael (2007) Changes in primary metabolism leading to citric acid overflow in aspergillus niger. Biotechnology Letters, 29 (2). pp. 181-190. ISSN 0141-5492

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Abstract

For citric acid-accumulating Aspergillus niger cells, the enhancement of anaplerotic reactions replenishing tricarboxylic acid cycle intermediates predisposes the cells to form the product. However, there is no increased citrate level in germinating spores and a complex sequence of developmental events is needed to change the metabolism in a way that leads to an increased level of tricarboxylic acid cycle intermediates in mycelia. A review of physiological events that cause such intracellular conditions, with the special emphasis on the discussion of hexose transport into the cells and regulation of primary metabolism, predominantly of glycolytic flux during the process, is presented.

Item type: Article
ID code: 10976
Keywords: anaplerosis, aspergillus niger, citric acid, hexose transport, primary metabolism, Pharmacy and materia medica, Biotechnology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 16 Nov 2011 11:37
    Last modified: 04 Sep 2014 20:56
    URI: http://strathprints.strath.ac.uk/id/eprint/10976

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