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Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy

Ferro, V.A. and Costa, R. and Carter, K.C. and Harvey, M.J. and Waterston, M.M. and Mullen, A. and Matschke, C. and Mann, J.F.S. and Colston, A. and Stimson, W.H. (2004) Immune responses to a GnRH-based anti-fertility immunogen, induced by different adjuvants and subsequent effect on vaccine efficacy. Vaccine, 22 (8). pp. 1024-31. ISSN 0264-410X

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Abstract

A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid and formulated with different adjuvants (non-ionic surfactant vesicles, aluminium hydroxide, Quil A, PLGA (poly(lactide-co-glycolide)/triacetin), and Quil A/PLGA). A comparison of the anti-fertility efficacy of the formulations was made by examining specific antibody levels, antibody subclasses, endocrine ablation and gonadal atrophy. The production of IgG2b antibody provided the best correlation for castration. PLGA was considered the most effective adjuvant as it produced a consistent anti-fertility response in all the treated animals.

Item type: Article
ID code: 10923
Keywords: GnRH, anti-fertility, vaccine, Pharmacy and materia medica, Infectious Diseases, Molecular Medicine, Public Health, Environmental and Occupational Health, veterinary(all), Immunology and Microbiology(all)
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology
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    Depositing user: Strathprints Administrator
    Date Deposited: 13 Jul 2011 09:30
    Last modified: 04 Sep 2014 19:30
    URI: http://strathprints.strath.ac.uk/id/eprint/10923

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