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A new approach to oligonucleotide labelling using Diels-Alder cycloadditions and detection by SERRS

Fruk, L. and Grondin, A. and Smith, W.E. and Graham, D. (2002) A new approach to oligonucleotide labelling using Diels-Alder cycloadditions and detection by SERRS. Chemical Communications (London), 2002 (18). pp. 2100-2101. ISSN 0009-241X

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Abstract

Diels-Alder cycloaddition has been used to add a benzotriazole azo dye to a diene tagged oligonucleotide to generate unique SERRS signals at 10 attomoles.