Strathprints logo
Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance

Zinselmeyer, B.H. and Dempster, J. and Gurney, A.M. and Wokosin, D.L. and Miller, M. and Ho, H. and Millington, O.R. and Smith, K.M. and Rush, C.M. and Parker, I. and Cahalan, M. and Brewer, J.M. and Garside, P. (2005) In situ characterisation of CD4+ t cell behaviour in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. Journal of Experimental Medicine, 201 (11). pp. 1815-1823. ISSN 0022-1007

[img]
Preview
PDF
308790.pdf - Published Version

Download (1MB) | Preview

Abstract

The behavior of antigen-specific CD4+ T lymphocytes during initial exposure to antigen probably influences their decision to become primed or tolerized, but this has not been examined directly in vivo. We have therefore tracked such cells in real time, in situ during the induction of oral priming versus oral tolerance. There were marked contrasts with respect to rate and type of movement and clustering between naive T cells and those exposed to antigen in immunogenic or tolerogenic forms. However, the major difference when comparing tolerized and primed T cells was that the latter formed larger and longer-lived clusters within mucosal and peripheral lymph nodes. This is the first comparison of the behavior of antigen-specific CD4+ T cells in situ in mucosal and systemic lymphoid tissues during the induction of priming versus tolerance in a physiologically relevant model in vivo.

Item type: Article
ID code: 10638
Keywords: lymphocytes, antigen, T cells , characterisation, CD4+t cells, mucosal, systemic lymphoid tissues , oral priming , tolerance, Pharmacy and materia medica, Immunology, Immunology and Allergy
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Physiology and Pharmacology
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Centre for Biophotonics
Depositing user: Strathprints Administrator
Date Deposited: 14 Nov 2011 10:42
Last modified: 24 Jul 2015 11:05
URI: http://strathprints.strath.ac.uk/id/eprint/10638

Actions (login required)

View Item View Item