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Phospholipid chlorohydrins cause ATP depletion and toxicity in human myeloid cells

Dever, G. and Stewart, L.J. and Pitt, A.R. and Spickett, C.M. (2003) Phospholipid chlorohydrins cause ATP depletion and toxicity in human myeloid cells. FEBS Letters, 540 (1-3). pp. 245-250. ISSN 0014-5793

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Chlorohydrins of stearoyl-oleoyl phosphatidylcholine (SOPC), stearoyl-linoleoyl phosphatidylcholine, and stearoyl-arachidonyl phosphatidylcholine were incubated with cultured myeloid cells (111,60) for 24 h, and the cellular ATP level was measured using a bioluminescent assay. The chlorohydrins caused significant depletion of cellular ATP in the range 10100 muM. The ATP depletion by the phospholipid chlorohydrins was slightly less than that of 4-hydroxy-2-nonenal, but greater than that of hexanal, trans-2-nonenal, and autoxidised palmitoyl-arachidonoyl phosphatidylcholine. SOPC chlorohydrin was also found to cause loss of viability in U937 cells, and thus phospholipid chlorohydrins could contribute to the formation of a necrotic core in advanced atherosclerotic lesions.