Earl, E.R. and Waterston, M.M. and Aughey, E. and Harvey, M.J. and Matschke, C. and Colston, A. and Ferro, V.A. (2006) Evaluation of two GnRH-I based vaccine formulations on the testes function of entire suffolk cross ram lambs. Vaccine, 24 (16). pp. 3172-3183. ISSN 0264-410XFull text not available in this repository. (Request a copy from the Strathclyde author)
A modified GnRH peptide (CHWSYGLRPG-NH2) was conjugated to tetanus toxoid (TT) or diphtheria toxoid (DT) and formulated with Quil A saponin or a sustained release injectible PLGA (poly(lactide-co-glycolide)/triacetin). For the Quil A formulations, two administrations of TT conjugate at 3-weekly intervals were followed by two booster injections with the DT conjugate in entire ram lambs. With the PLGA formulations, only two injections were administered; the first containing TT and the second DT at 6-weekly intervals. Evaluation was carried out by comparing the specific antibody levels produced in relationship to hormone profiles and testicular changes. The Quil A formulation was considered the most effective, as it caused significant reduction in testosterone and follicle stimulating hormone levels, resulting in marked suppression of spermatogenesis.
|Keywords:||GnRH, vaccine, anti-fertility, Pharmacy and materia medica, Infectious Diseases, Molecular Medicine, Public Health, Environmental and Occupational Health, veterinary(all), Immunology and Microbiology(all)|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||04 Oct 2011 09:35|
|Last modified:||27 Apr 2016 12:45|