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The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by University of Strathclyde researchers, including by Strathclyde researchers from the Department of Computer & Information Sciences involved in researching exciting new applications for mobile and smartphone technology. But the transformative application of mobile technologies is also the focus of research within disciplines as diverse as Electronic & Electrical Engineering, Marketing, Human Resource Management and Biomedical Enginering, among others.

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Synthesis and neuromuscular blocking activity of 16β-piperidinosteroidal derivatives

Jindal, D.P. and Piplani, P. and Fajrak, H. and Prior, C.B. and Marshall, I.G. (2001) Synthesis and neuromuscular blocking activity of 16β-piperidinosteroidal derivatives. European Journal of Medicinal Chemistry, 36 (2). pp. 195-202. ISSN 0223-5234

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Abstract

The synthesis and pharmacological profiles of some new steroidal mono- and bisquaternary ammonium derivatives have been described. The compounds featured have been conceptually derived structurally from two lead structures: pancuronium bromide 1 and chandonium iodide 2. In vitro and in vivo neuromuscular blocking studies have indicated the monoquaternary compound 15 to be less active than the bisquaternary compounds 10 and 11. The compound 11 has been found to be more active than d-tubocurarine.