Strathprints Home | Open Access | Browse | Search | User area | Copyright | Help | Library Home | SUPrimo

Synthesis and neuromuscular blocking activity of 16β-piperidinosteroidal derivatives

Jindal, D.P. and Piplani, P. and Fajrak, H. and Prior, C.B. and Marshall, I.G. (2001) Synthesis and neuromuscular blocking activity of 16β-piperidinosteroidal derivatives. European Journal of Medicinal Chemistry, 36 (2). pp. 195-202. ISSN 0223-5234

Full text not available in this repository. (Request a copy from the Strathclyde author)

Abstract

The synthesis and pharmacological profiles of some new steroidal mono- and bisquaternary ammonium derivatives have been described. The compounds featured have been conceptually derived structurally from two lead structures: pancuronium bromide 1 and chandonium iodide 2. In vitro and in vivo neuromuscular blocking studies have indicated the monoquaternary compound 15 to be less active than the bisquaternary compounds 10 and 11. The compound 11 has been found to be more active than d-tubocurarine.

Item type: Article
ID code: 10493
Keywords: monoquaternary, bisquaternary, piperidine, chick biventer, anaesthetized cat, carbachol, nondepolarizing, steroidal, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 29 Aug 2011 15:04
    Last modified: 12 Mar 2012 10:53
    URI: http://strathprints.strath.ac.uk/id/eprint/10493

    Actions (login required)

    View Item