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[DELTA]9-tetrahydrocannabinol-induced alterations in limbic system glucose use in the rat

Brett, Ros and MacKenzie, Fiona and Pratt, Judith (2001) [DELTA]9-tetrahydrocannabinol-induced alterations in limbic system glucose use in the rat. NeuroReport, 12 (16). pp. 3573-3577. ISSN 0959-4965

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Abstract

The effects of Δ9-tetrahydrocannabinol (THC) on neural activity in the rat were investigated using [14C]2-deoxyglucose autoradiography to measure local cerebral glucose use. Overall, THC reduced glucose use at 5 mg/kg and slightly increased it at 1 mg/kg. Significant reductions were seen at the higher dose in regions of the hippocampus and limbic system, and in structures associated with sensory and sensorimotor process ing, consistent with the effects of THC on memory, sensory perception and motor control. Glucose use was increased in the shell of the nucleus accumbens at 1 mg/kg but not reduced at 5 mg/kg. This may reflect increases in activity in mesolimbic reward pathways which at the higher dose are mitigated by reduced glutamatergic outflow from the hippocampus.

Item type: Article
ID code: 10465
Keywords: cannabinoids, 2-deoxyglucose autoradiography, Delta(9)-tetrahydrocannabinol, hippocampus, nucleus accumbens, somatosensory system, Pharmacy and materia medica, Neuroscience(all)
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 30 Sep 2010 19:58
Last modified: 04 Sep 2014 19:01
URI: http://strathprints.strath.ac.uk/id/eprint/10465

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