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The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells

Long, J.S.L. and Pyne, N.J. and Pyne, S. (2006) The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells. Prostaglandins and Other Lipid Mediators, 79 (3-4). pp. 278-286. ISSN 1098-8823

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Abstract

Both acute and chronic hypoxia had no effect on S1P1, S1P3 or LPA1 receptor transcript expression in human pulmonary smooth muscle cells. However, acute hypoxia increased sphingosine kinase SK1/2 and LPP1 mRNA transcript levels, while chronic hypoxia increased SK1 mRNA transcript alone. Acute hypoxia had no effect on S1P-, PDGF- or phorbol ester (PMA)-stimulated activation of ERK-1/2, but increased the ability of S1P to activate p38 MAPK. Chronic hypoxia increased the ability of S1P to stimulate the phosphorylation of ERK-1/2. Therefore, we have demonstrated for the first time that hypoxia can lead to marked changes in the expression of genes involved in S1P production and may modify post S1P receptor signal transduction pathways.

Item type: Article
ID code: 10412
Keywords: sphingosine 1-phosphate receptor, lysophosphatidic acid receptor, sphingosine kinase, lipid phosphate phosphatase, extracellular signal regulated kinase, Pharmacy and materia medica, Biochemistry, Cell Biology, Physiology, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
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Depositing user: Strathprints Administrator
Date Deposited: 01 Oct 2010 19:42
Last modified: 04 Sep 2014 20:24
URI: http://strathprints.strath.ac.uk/id/eprint/10412

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