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Naive t-cell receptor transgenic t cells help memory b cells produce antibody

Duffy, D. and Yang, C.P. and Heath, A. and Garside, P. and Bell, E.B. (2006) Naive t-cell receptor transgenic t cells help memory b cells produce antibody. Immunology, 119. pp. 376-384. ISSN 0019-2805

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Abstract

Injection of the same antigen following primary immunization induces a classic secondary response characterized by a large quantity of high-affinity antibody of an immunoglobulin G class produced more rapidly than in the initial response – the products of memory B cells are qualitatively distinct from that of the original naive B lymphocytes. Very little is known of the help provided by the CD4 T cells that stimulate memory B cells. Using antigen-specific T-cell receptor transgenic CD4 T cells (DO11.10) as a source of help, we found that naive transgenic T cells stimulated memory B cells almost as well (in terms of quantity and speed) as transgenic T cells that had been recently primed. There was a direct correlation between serum antibody levels and the number of naive transgenic T cells transferred. Using T cells from transgenic interleukin-2-deficient mice we showed that interleukin-2 was not required for a secondary response, although it was necessary for a primary response. The results suggested that the signals delivered by CD4 T cells and required by memory B cells for their activation were common to both antigen-primed and naive CD4 T cells.

Item type: Article
ID code: 10396
Keywords: adoptive transfer, transgenic, memory, CD45RB, CD4 T cells, Pharmacy and materia medica
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 04 Oct 2011 10:25
    Last modified: 16 Jul 2013 21:52
    URI: http://strathprints.strath.ac.uk/id/eprint/10396

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