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Delivery systems: a vaccine strategy for overcoming mucosal tolerance?

Ferro, V.A. and Mann, J.F.S. and Acevedo, R. and del Campo, J. and Pere, O. (2009) Delivery systems: a vaccine strategy for overcoming mucosal tolerance? Expert Review of Vaccines, 8 (1). pp. 103-112.

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Abstract

Antigens administered via the oral and, to a lesser extent, the nasal route are potentially able to invoke tolerance, resulting in a nonreactive immune response. This has been a hurdle for mucosal vaccine development and yet the desire to induce protective local and systemic responses, with pain-free and more convenient products, has been the impetus driving mucosal vaccine R&D. Nevertheless, few mucosal vaccines have reached the marketplace and products are still treated with caution, particularly where live organisms are utilized. In this review, we examine the use of delivery systems with adjuvant properties as key components in a vaccine strategy that does not require the use of live vectors to overcome tolerance and have exemplified their success in mucosal vaccines, concentrating on the nasal and oral routes of administration.

Item type: Article
ID code: 10391
Keywords: adjuvant, delivery system, mucosal immunization, tolerance, vaccine, Pharmacy and materia medica, Immunology, Drug Discovery, Molecular Medicine, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences > Immunology
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    Depositing user: Strathprints Administrator
    Date Deposited: 23 Jun 2010 13:59
    Last modified: 04 Sep 2014 21:30
    URI: http://strathprints.strath.ac.uk/id/eprint/10391

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