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Mucosal immunisation : successful approaches to targeting different tissues

Ferro, V.A. and Carter, K.C. (2006) Mucosal immunisation : successful approaches to targeting different tissues. Methods, 38 (2). pp. 61-64. ISSN 1046-2023

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Abstract

Vaccines have been developed for clinical and veterinary applications to protect against infectious diseases [1,2], to provide therapies against cancer [3,4], addictions [5], and allergies and autoimmune diseases [6,7], and to prevent pregnancy [4,8,9]. In general, traditional immunisation relies on the production of antibody and cell-mediated responses directed against specific antigens from a pathogen, usually an attenuated or subunit protein/peptide derivative, co-administered with an adjuvant [10]. More recently, DNA, or primed, pre-existing leukocytes or antigen- presenting cells have been used to prime vaccinees [11]. The choice of vaccination procedures is complex, and the results may be dependent on many factors such as dose, type of adjuvant, time between inoculation, and methods used to evaluate efficacy [12,13]. In addition, immune responses to an antigen vary with age, gender, and health status, factors that the vaccination regimen needs to take into account [14–16]. To date, and with a few exceptions, vaccines are generally given by subcutaneous or intramuscular injection. This invasive procedure ensures that the correct dose is given, often forming a depot of antigen and the overall effect is to stimulate the appropriate action by immune cells [10].

Item type: Article
ID code: 10385
Keywords: mucosal immunization, tissue, Pharmacy and materia medica, Biochemistry, Genetics and Molecular Biology(all), Molecular Biology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 04 Oct 2011 11:54
    Last modified: 04 Sep 2014 20:01
    URI: http://strathprints.strath.ac.uk/id/eprint/10385

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