Picture of athlete cycling

Open Access research with a real impact on health...

The Strathprints institutional repository is a digital archive of University of Strathclyde's Open Access research outputs. Strathprints provides access to thousands of Open Access research papers by Strathclyde researchers, including by researchers from the Physical Activity for Health Group based within the School of Psychological Sciences & Health. Research here seeks to better understand how and why physical activity improves health, gain a better understanding of the amount, intensity, and type of physical activity needed for health benefits, and evaluate the effect of interventions to promote physical activity.

Explore open research content by Physical Activity for Health...

Cardiac ryanodine receptor phosphorylation by CaM Kinase II : Keeping the balance right

Currie, S. (2009) Cardiac ryanodine receptor phosphorylation by CaM Kinase II : Keeping the balance right. Frontiers in Bioscience, 14. pp. 5134-5156. ISSN 1093-9946

Full text not available in this repository. Request a copy from the Strathclyde author

Abstract

Phosphorylation of the cardiac ryanodine receptor (RyR(2)) is a key mechanism regulating sarcoplasmic reticulum (SR) Ca2+ release. Differences in opinion have arisen over the importance assigned to specific phosphorylation sites on RyR(2), over the kinase (s) suggested to directly phosphorylate RyR(2) and surrounding the possibility that altered phosphorylation of RyR(2) is associated with contractile dysfunction observed in heart failure. Ca2+/calmodulin dependent protein kinase II (CaMKII) can phosphorylate RyR(2) and modulate its activity. This phosphorylation positively modulates cardiac inotropic function but in extreme situations such as heart failure, elevated CaMKII activity can adversely increase Ca2+ release from the SR and lead to arrhythmogenesis. Although other kinases can phosphorylate RyR(2), most notably cAMP-dependent protein kinase (PKA), evidence for a key role of CaMKII in mediating RyR(2)-dependent Ca2+ release is emerging. Future challenges include (i) fully identifying mechanisms of CaMKII interaction with the RyR(2) complex and (ii) given the ubiquitous expression of CaMKII, developing selective strategies to modulate RyR(2)-targeted CaMKII activity and allow improved understanding of its role in normal and diseased heart.