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The Strathprints institutional repository is a digital archive of University of Strathclyde research outputs.

Strathprints serves world leading Open Access research by the University of Strathclyde, including research by the Strathclyde Institute of Pharmacy and Biomedical Sciences (SIPBS), where research centres such as the Industrial Biotechnology Innovation Centre (IBioIC), the Cancer Research UK Formulation Unit, SeaBioTech and the Centre for Biophotonics are based.

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Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

Kane, K.A. and Michael, G. and Coker, S.J. (2008) Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. British Journal of Pharmacology, 154 (7). pp. 1414-1426. ISSN 0007-1188

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Abstract

Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.