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Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

Kane, K.A. and Michael, G. and Coker, S.J. (2008) Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. British Journal of Pharmacology, 154 (7). pp. 1414-1426. ISSN 0007-1188

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Abstract

Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.

Item type: Article
ID code: 10370
Keywords: E-4031, guinea pig, HMR1556, IKr, IKs, K+ channel blockers, proarrhythmia, repolarization reserve, torsade de pointes, Pharmacy and materia medica, Pharmacology
Subjects: Medicine > Pharmacy and materia medica
Department: Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences
Related URLs:
    Depositing user: Strathprints Administrator
    Date Deposited: 22 Jun 2010 11:49
    Last modified: 04 Sep 2014 21:25
    URI: http://strathprints.strath.ac.uk/id/eprint/10370

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