Kane, K.A. and Michael, G. and Coker, S.J. (2008) Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. British Journal of Pharmacology, 154 (7). pp. 1414-1426. ISSN 0007-1188
Full text not available in this repository. (Request a copy from the Strathclyde author)Official URL: http://dx.doi.org/10.1038/bjp.2008.169
Abstract
Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.
| Item type: | Article |
|---|---|
| ID code: | 10370 |
| Keywords: | E-4031, guinea pig, HMR1556, IKr, IKs, K+ channel blockers, proarrhythmia, repolarization reserve, torsade de pointes, Pharmacy and materia medica |
| Subjects: | Medicine > Pharmacy and materia medica |
| Department: | Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences |
| Related URLs: | |
| Depositing user: | Strathprints Administrator |
| Date Deposited: | 22 Jun 2010 11:49 |
| Last modified: | 04 Oct 2012 12:38 |
| URI: | http://strathprints.strath.ac.uk/id/eprint/10370 |
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