Kane, K.A. and Michael, G. and Coker, S.J. (2008) Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs. British Journal of Pharmacology, 154 (7). pp. 1414-1426. ISSN 0007-1188Full text not available in this repository. (Request a copy from the Strathclyde author)
Torsade de pointes (TdP) can be induced in several species by a reduction in cardiac repolarizing capacity. The aim of this study was to assess whether combined IKr and IKs blockade could induce TdP in anaesthetized guinea pigs and whether short-term variability (STV) or triangulation of action potentials could predict TdP.
|Keywords:||E-4031, guinea pig, HMR1556, IKr, IKs, K+ channel blockers, proarrhythmia, repolarization reserve, torsade de pointes, Pharmacy and materia medica, Pharmacology|
|Subjects:||Medicine > Pharmacy and materia medica|
|Department:||Faculty of Science > Strathclyde Institute of Pharmacy and Biomedical Sciences|
|Depositing user:||Strathprints Administrator|
|Date Deposited:||22 Jun 2010 10:49|
|Last modified:||29 Apr 2016 10:28|