Kennedy, A.R. and Okoth, M.O. and Sheen, D.B. and Sherwood, J.N. and Teat, S.J. and Vrcelj, R.M. (2003) Cephalexin: a channel hydrate. Acta Crystallographica Section C: Crystal Structure Communications, 59 (11). o650-o652. ISSN 0108-2701Full text not available in this repository. (Request a copy from the Strathclyde author)
The antibiotic cephalexin [systematic name: d-7-(2-amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid] forms a range of isomorphic solvates, with the maximum hydration state of two water molecules formed only at high relative humidities. The water content of the structure reported here (C16H17N3O4S·1.9H2O) falls just short of this configuration, having three independent cephalexin molecules, one of which is disordered, and 5.72 observed water molecules in the asymmetric unit. The facile nature of the cephalexin solvation/desolvation process is found to be facilitated by a complex channel structure, which allows free movement of solvent in the crystallographic a and b directions.
|Keywords:||antibiotic cephalexin, isomorphic solvates, hydration, humidities, crystallographic, Chemistry, Biochemistry, Genetics and Molecular Biology(all)|
|Subjects:||Science > Chemistry|
|Department:||Faculty of Science > Pure and Applied Chemistry
|Depositing user:||Catriona Mccallum|
|Date Deposited:||15 May 2006|
|Last modified:||06 Jan 2017 03:28|